Non-ataxia signs in Brazilian individuals with spinocerebellar ataxia type 3

Abstract Introduction: Spinocerebellar ataxia 3 (SCA3) is a hereditary disease associated with progressive cerebellar and extracerebellar degeneration. Although there no effective therapy for SCA3, some of its symptoms can be relieved symptomatic treatment. Identifying the presence this signs in patients may contribute to their clinical management thus improve quality life. Objective: To identify frequency non-ataxia sample Brazilian individuals SCA3 investigate association severity duration disease. Methods: This cross-sectional study. The inclusion criteria study were participants should diagnosed between 18 70 years old. exclusion score less than points on Mini Mental State Examination (MMSE) those other neurological or orthopedic problems. Twenty-three evaluated by Inventory Non-ataxia Signs (INAS) Scale Assessment Rating Ataxia (SARA). Results: median found INAS was [median (min-max)] (0-6) 10 (2-23) SARA. Only one participant did not show non-ataxic signs. most prevalent manifestations areflexia, urinary dysfunction, hyperreflexia spasticity. Spearman correlation test indicated moderate significant SARA scores (rho = 0.428, 95% CI 0.39-0.704, p 0.033). There 0.003, -0.398-0.704, 0.393). Conclusion: Areflexia, spasticity We identified severity. findings help professionals dealing these patients.